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| Product Name | Recombinant Human E3 ubiquitin-protein ligase parkin |
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| Description | 1-465aa; Full Length. MW: 67.6kD. Purity >90% as determined by SDS-PAGE. Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in |
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| Size | 0.01 mg (E-Coli), 0.01 mg (Baculovirus), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Parkinson juvenile disease protein 2; Parkinson disease protein 2] |
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| Gene, Accession, CAS # | PARK2, Gene ID: 5071, Accession: NP_004553.2 |
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| Catalog # | MBS1070644 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase parkin from MYBIOSOURCE INC. |
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| Product Specific References | Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N.Nature 392:605-608(1998) Evidence for the presence of full-length PARK2 mRNA and Parkin protein in human blood.Kasap M., Akpinar G., Sazci A., Idrisoglu H.A., Vahaboglu H.Neurosci. Lett. 460:196-200(2009) Functional and molecular diversity of parkin.D'Agata V., Scapagnini G., Cavallaro S.Homo sapiens PARK2 transc |
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