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| Product Name | Recombinant Human E3 ubiquitin-protein ligase RAD18 |
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| Description | 1-495aa; Full Length. MW: 72.2kD. Purity >90% as determined by SDS-PAGE. E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 ] |
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| Gene, Accession, CAS # | RAD18, Gene ID: 56852, Accession: NP_064550.3 |
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| Catalog # | MBS1355759 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase RAD18 from MYBIOSOURCE INC. |
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| Product Specific References | Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.Tateishi S., Sakuraba Y., Masuyama S., Inoue H., Yamaizumi M.Proc. Natl. Acad. Sci. U.S.A. 97:7927-7932(2000) The human RAD18 gene product interacts with HHR6A and HHR6B.Xin H., Lin W., Sumanasekera W., Zhang Y., Wu X., Wang Z.Nucleic Acids Res. 28:2847-2854(2000) Identification of human RAD18 (hHR18), a homolog of yeast RAD18.Jang Y., Chae S.Complete sequencing and characterization o |
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