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| Product Name | Recombinant Human E3 ubiquitin-protein ligase SMURF2 |
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| Description | 1-748aa; Full Length. MW: 113.54kD. Purity >90% as determined by SDS-PAGE. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a sta |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2 ] |
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| Gene, Accession, CAS # | SMURF2, Gene ID: 64750, Accession: NP_073576.1 |
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| Catalog # | MBS1357228 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase SMURF2 from MYBIOSOURCE INC. |
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| Product Specific References | Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.Kavsak P., Rasmussen R.K., Causing C.G., Bonni S., Zhu H., Thomsen G.H., Wrana J.L.Mol. Cell 6:1365-1375(2000) Smurf2 Is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.Lin X., Liang M., Feng X.-H.J. Biol. Chem. 275:36818-36822(2000) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.Zhang Y., Cha |
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