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| Product Name | Recombinant Human E3 ubiquitin-protein ligase TRAIP (TRAIP) |
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| Description | 1-469aa. MW: 58.8 kDa. Purity >85% as determined by SDS-PAGE. E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. Involved in response to genotoxic lesions during genome replication. Promotes H2AX a |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [RING finger protein 206; RING-type E3 ubiquitin transferase TRAIPCurated; TRAF-interacting protein] |
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| Gene, Accession, CAS # | TRAIP, Gene ID: 10293, Accession: NP_005870.2 |
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| Catalog # | MBS7110965 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase TRAIP (TRAIP) from MYBIOSOURCE INC. |
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| Product Specific References | TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. Lee S.Y., Lee S.Y., Choi Y.J. Exp. Med. 185:1275-1285 (1997) |
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