| 产品详情 |
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| Product Name | Bisindolylmaleimide I |
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| Description | Purity >95%. Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCAlpha, Beta1, Beta2, Gamma, Delta, and e isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3Beta immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione, BIM I, Goe 6850, GF 109203X |
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| Gene, Accession, CAS # | CAS: 133052-90-1 |
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| Catalog # | LS-H6832 |
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| Order / More Info | Bisindolylmaleimide I from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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