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| Product Name | LGR5, Recombinant, Human, aa22-561, His-Tag (Leucine-rich Repeat-containing G-Protein Coupled Receptor 5) |
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| Description | Purity ~85% (SDS-PAGE). Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by Extracellular domain Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. Source: Recombinant protein corresponding to aa22-561 from human LGR5, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~62.37kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: O75473 |
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| Catalog # | 374030 |
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| Order / More Info | LGR5, Recombinant, Human, aa22-561, His-Tag (Leucine-rich Repeat-containing G-Protein Coupled Receptor 5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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