| 产品详情 |
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| Product Name | CD89 (Fc alpha R, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. FCAR, also called FcαRI or CD89, is a variably glycosylated 50-100 kD myeloid-specific type I transmembrane (TM) Fc receptor for IgA that is a member of the multichain immune recognition receptor (MIRR) family. 1-3 Human FCAR contains a 21 amino acid (aa) signal sequence and extracellular (ECD), TM and cytoplasmic domains of 206, 19 and 41 aa, respectively. 4 Arg230 within the TM domain supports interaction with the ITAM-containing signaling subunit, FcRγ, which contains a TM Asp. 5-7 Two ECD C2-type Ig-like domains (EC1 and 2) are oriented at right angles. 8 Up to two molecules of FCAR can bind one molecule of serum IgA via EC1. 8 Many splice variants have been reported, but only two have been identified as proteins. 9, 10 The a.2 form, which lacks 22 aa just prior to the TM domain, is exclusively expressed in alveolar macrophages. The a.3 form lacks EC2. FCAR binds monomeric, polymeric and secretory I |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2440-01H |
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| Order / More Info | CD89 (Fc alpha R, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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