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| Product Name | CD86, Fc Chimera, Recombinant, Human, aa20-239 (B7-2, B70, ETC-1) |
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| Description | Purity ~95% (SDS-PAGE). B7-2, also known as CD86, B70, and ETC-1, is a 60-100kD variably glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance (1, 2). Mature human B7-2 consists of a 224 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21aa transmembrane segment, and a 61aa cytoplasmic tail (3, 4). Within the ECD, human B7-2 shares 59% aa sequence identity with mouse and rat B7-2. Alternative splicing of human B7-2 generates additional isoforms that lack both Ig-like domains or a region that includes the transmembrane segment. B7-2 is highly expressed on activated antigen presenting cells (APC), e.g. B cells, dendritic cells, and monocytes (4-7), as well as on vascular endothelial cells (8). B7-2 and the closely related B7-1/CD80 exhibit overlapping but distinct functional properties. Their binding to CD28, which is constitutively expr |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_008820 |
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| Catalog # | 145781 |
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| Order / More Info | CD86, Fc Chimera, Recombinant, Human, aa20-239 (B7-2, B70, ETC-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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