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| Product Name | IRTK Activator III, DDN (5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquino) |
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| Description | Purity ~98% (HPLC). An orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5uM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20mg/kg, p.o.). Formula: C14H8Cl2O6 Molecular Weight: 343.1 Solubility: DMSO (25mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217468 |
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| Order / More Info | IRTK Activator III, DDN (5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquino) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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