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| Product Name | SPHK1, Recombinant, Human, GST-Tag (Sphingosine Kinase 1, SPHK) |
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| Description | Purified (~70-90%). SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP) which is a novel lipid messenger with both intracellular and extracellular functions. Various stimuli increase cellular levels of SPP by activation of SPHK1. Competitive inhibitors of SPHK1 block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors. SPHK1/sphingosine-1-phosphate pathway contributes to colon carcinogenesis. SPHK1 plays a key role in the generation and release of proinflammatory mediators triggered by anaphylatoxins from human macrophages and also is involved in the process of immune cell motility. Source: Recombinant protein corresponding to human SPHK1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~71kD Specific Activity: 450nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: BC008040 |
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| Catalog # | 500455 |
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| Order / More Info | SPHK1, Recombinant, Human, GST-Tag (Sphingosine Kinase 1, SPHK) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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