| 产品详情 |
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| Product Name | AM80 |
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| Description | Purity >98%. AM80 is a retinoic acid receptor agonist that is selective for RARAlpha (Kd = 62 nM; AC50 = 1.46 nM) compared to RARBeta (Kd = 280 nM; AC50 = 6.87 nM) and RARGamma (Kd = 816 nM; AC50 = 148.7 nM). It demonstrates greater specific binding to RARAlpha compared to retinoic acid , which exhibits little selectivity across RARAlpha, Beta, or Gamma. AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-benzoic acid, Amnolake, NSC 608000, Retinobenzoic Acid, Tamibarotene |
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| Gene, Accession, CAS # | CAS: 94497-51-5 |
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| Catalog # | LS-H6495 |
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| Price | |
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| Order / More Info | AM80 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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