| 产品详情 |
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| Antigenic Specificity | Smac/DIABLO |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 100ul |
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| Concentration | 1ug/ul |
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| Applications | WB, IHC-P, IF(IHC-P) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Smac/DIABLO Polyclonal Antibody. • Target Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 a |
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| Immunogen | KLH conjugated synthetic peptide derived from human Smac . Immunogen Range: 177-211/239 |
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| Other Names | SMAC; DFNA64; Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; DIABLO |
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| Gene, Accession # | Gene ID: 56616, SwissProt: Q9NR28 |
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| Catalog # | bs-1298R |
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| Price | |
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| Order / More Info | Smac/DIABLO Antibody from BIOSS ANTIBODIES |
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| Product Specific References | Liu, B. et al. (2013) Int J Mol Med.32(3):615-22. PubMed: 23857156 |
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