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| Product Name | Phospholipase A2, Secretory, Group IB, Recombinant, Human (PLA2, sPLA2-IB) |
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| Description | Purity > 95% (SDS-PAGE); Three-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography before and after refolding. Group IB secretory phospholipase A2 (sPLA2-IB) mediates cell proliferation, cell migration, hormone release and eicosanoid production via its receptor in peripheral tissues. In the CNS, high-affinity binding sites of sPLA2-IB have been documented. sPLA2-IB induced neuronal cell death in a concentrationdependent manner depending on PGD2 metabolites, especially Delta12-PGJ2 that might mediate sPLA2-IB-induced apoptosis. The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of lowmolecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense. Description: The Recombinant Human Secreted Phospholipase A2-IB is manufactured with N-terminal fusionf HisTag. The Recombinant Human Secreted Phos |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4074-06D3 |
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| Order / More Info | Phospholipase A2, Secretory, Group IB, Recombinant, Human (PLA2, sPLA2-IB) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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