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| Product Name | Phospholipase A2, Secretory, Group IID, Recombinant, Human (PLA2, sPLA2-IID) |
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| Description | Purity ≥ 95% (SDS-PAGE); Ni-NTA affinity chromatography. Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators. The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of lowmolecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense. This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso- PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci. In mice, sPLA2 expression significantly influences HDL particle size and composition and dem |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4074-06E5 |
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| Order / More Info | Phospholipase A2, Secretory, Group IID, Recombinant, Human (PLA2, sPLA2-IID) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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