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| Product Name | Twisted Gastrulation Protein, Recombinant, Human (TSG) |
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| Description | Purity ~95% (SDS-PAGE). Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 198aa protein containing the BMP/TGFbeta binding portion of the full length TSG protein. Source: Recombinant protein corresponding to human Twisted Gastrulation Protein, expressed in E. coli. Molecular Weight: ~22.2kD Biological Activity: Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is ≤2.0ug/ml of TSG. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV H |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Twisted Gastrulation Protein |
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| Gene, Accession, CAS # | TSG, Gene ID: 57045, SwissProt: Q9GZX9 |
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| Catalog # | 220365 |
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| Order / More Info | Twisted Gastrulation Protein, Recombinant, Human (TSG) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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