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| Product Name | CD134 Human, IgG2a Fc Mouse, Fusion Protein (OX40) |
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| Description | Purified by size exclusion chromatography. Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2). The CD134 costimulatory pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (5). Blockade of this interaction in mouse abrogated immunological effects in several models of immflamation and rejection (6,7,8,9). CD134-muIg fusion protein binds to CD134L on Human Umbilical Cord Endothelial Cells (HUVEC). Human CD134(OX40)-muIg Fusion Protein* Molecular Structure: A soluble molecule consisting of the extracellular (185 aa) domain of human CD134 fused to the murine IgG2a Fc (232 aa). Predicted monomeric non-glysylated weight is 45.6kD. Fusion construct is dimeric and runs about 105k |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA FC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2515-26A |
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| Order / More Info | CD134 Human, IgG2a Fc Mouse, Fusion Protein (OX40) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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