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| Product Name | CD40 Human, IgG2a Fc Mouse, Fusion Protein (Preservative Free) |
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| Description | Purified by affinity chromatography. Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (1). CD40 muIg fusion protein is recognized by anti-human CD40 antibody and binds to human CD154. This binding can be blocked by anti-CD154 antibody. Molecular Structure: A soluble fusion protein consisting of the extracellular (173aa) domain of human CD40 fused to murine IgG2a Fc (233aa). Functional Application: CD40 Human, IgG2a Fc Mouse, Fusion Protein blocks binding of anti-human CD40 to Raji human tumor cells. Flow Cytometry Protocol: 1. Jurkat-4G (a CD154 positive subclone of Jurkat)cells were stimulated 6 hours in the presence of PMA and Ionomycin (to increase CD154 expression). 2. Five x 10e5 cel |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA FC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2392-02KX |
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| Order / More Info | CD40 Human, IgG2a Fc Mouse, Fusion Protein (Preservative Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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