| 产品详情 |
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| Product Name | Vildagliptin |
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| Description | Purity >98%. Glyptins are a class of oral antihyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. In addition to having use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammatory effects. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM). It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein Alpha. Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile |
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| Gene, Accession, CAS # | CAS: 274901-16-5 |
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| Catalog # | LS-H10430 |
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| Order / More Info | Vildagliptin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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