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| Product Name | Vimentin, Recombinant, Human (FLJ36605, VIM) (BSA Free) |
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| Description | Purity ~ 95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ~1EU/ug (LAL). Vimentin is a 57kD class III intermediate filament (IF) protein that belongs to the intermediate filament family. It is the predominant IF in cells of mesenchymal origin. The human Vimentin cDNA encodes a 466aa protein that contains head and tail regions with multiple regulatory Ser/Thr phosphorylation sites, and a central rod domain with three coiled-coil regions separated by linkers. Human Vimentin shares 97-98% aa identity with mouse, rat, ovine, bovine and canine Vimentin. Sixteen Vimentin coiled-coil dimers self-assemble to form intermediate filaments. These filaments then anneal longitudinally to form non-polarized fibers that support cell structure and withstand stress. IF fibers are highly dynamic, and half-life depends on the balance between kinase and phosphatase activity. Interactions of head and tail domains link IFs with other structures such as actin |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P08670 |
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| Catalog # | V2122-15B |
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| Order / More Info | Vimentin, Recombinant, Human (FLJ36605, VIM) (BSA Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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