| 产品详情 |
| Edit |   |
|---|
| Product Name | b-Catenin/Tcf Inhibitor II, PKF118-310 |
|---|
| Description | Purity ~95% (HPLC). A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts b-catenin-Tcf4 interaction (IC50=0.8uM in cell-free binding assays) and inhibits b-catenin-regulated cellular transcription activity (IC50=0.3uM in HCT116-based reporter assays). PKF118-310 is demonstrated to reverse b-catenin, but not siamois, mRNA-induced ventral body axis formation in Xenopus embryos, while direct tumor site injection (1mg/kg/0.5 wk) in HepG2 xenograph mice is shown to increase the number of apoptotic cells and decrease the expression of b-catenin target genes (cyclin D1, c-Myc, survivin) in the tumor mass, resulting in an effective tumor growth retardation (by ~60% after a 4-wk treatment period) in vivo. Formula: C7H7N5O2 Molecular Weight: 193.2 Solubility: DMSO (100mg/ml) |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | b-Catenin/Tcf Inhibitor II, PKF118-310 (1,6-Dimethylpyrimido[5,6-e][1,2,4]triazine-5,7-dione, Wnt Pathway Inhibitor IV) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217207 |
|---|
| Price | |
|---|
| Order / More Info | b-Catenin/Tcf Inhibitor II, PKF118-310 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|