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| Product Name | Pan-Ras Activation Assay |
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| Description | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Ras, a 21 kDa protein, regulates a variety of biological response pathways that include cell growth, cell transformation and tumor invasion. Like other small GTPases, Ras regulates molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. In its active (GTP-bound) state, Ras binds specifically to the Ras-binding dom |
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| Size | 5 assays, 20 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168250 |
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| Order / More Info | Pan-Ras Activation Assay from MYBIOSOURCE INC. |
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| Product Specific References | 1. Bar-Sagi D., and Hall A. (2000) Cell 103: 227-38.2. de Rooij J., and Bos J. L. (1997) Oncogene 14: 623-5.1. Nikolos, F. et al. (2014). ERbeta Regulates NSCLC Phenotypes by Controlling Oncogenic RAS Signaling. Mol Cancer Res. 12:843-854.2. Ohashi, K. et al. (2012). Lung Cancers with Acquired Resistance to EGFR Inhibitors Occasionally Harbor BRAF Gene Mutations but Lack Mutations in KRAS, NRAS, or MEK1. PNAS. 109:E2127-E2133.3. Harmon, B. et al. (2008). Induction of the Gaq signaling cascade by the human immunodeficiency virus envelope is required for virus entry. J. Virol. 82:9191-9205.4. Camalier, C.E. et al. (2010). Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. Cancer Prev. Res. 3:359-370.5. Geryk-Hall, M. et al. (2010). Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. Mol. Cancer Ther. 9:1111-119. |
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