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| Product Name | LIF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. Source: Recombinant protein corresponding to human LIF expressed in CHO cells. Molecular Weight: ~20kD Biological Activity: The ED50 was determined by the dose-dependent differentiation of M1 myeloid leukemic cells was found to be in the range of 0.01ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LIF, Recombinant, Human (LIF, Differentiation-Stimulating Factor, D Factor, Melanoma-Derived LPL inhibitor, MLPLI, INN=Emfilermin, HILDA, Leukemia Inhibitory Factor) |
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| Gene, Accession, CAS # | SwissProt: P15018 |
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| Catalog # | 500209 |
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| Order / More Info | LIF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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