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| Product Name | LIF, Recombinant, Human (Leukemia Inhibitory Factor, hLIF) (Carrier Free) |
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| Description | Purity ~98% (SDS-PAGE). Leukemia Inhibitory Factor (LIF) is a 208kD pleiotrophic factor belonging to the IL-6 superfamily of cytokines (1). LIF is expressed in a number of tissues and cell types. The LIF receptor is a heterodimer comprised of LIF-R (gp190) and gp130, a common signal transducer for IL-6-type cytokines (1). Depending on cell type and context, LIF/LIF-R can activate Erk, PI3K, and Jak1/Stat1/3 pathways (1,2). LIF has a diverse array of biological activities. Murine embryonic stem cells are dependent on LIF for pluripotency and self-renewal in vitro (1). Exercise- induced LIF secretion in muscle induces myoblast proliferation, suggesting that LIF may play a role in exercise-induced muscle hypertrophy (2). LIF also negatively regulates Th2 and Th17 cell differentiation (3,4). Source: Recombinant protein corresponding to Ser23-Phe202 from human LIF, expressed in E. coli. Molecular Weight: ~20kD Biological Activity: Determined in a TF-1 cell proliferation assay. The ED50 of e |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3976, SwissProt: P15018 |
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| Catalog # | 137463 |
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| Order / More Info | LIF, Recombinant, Human (Leukemia Inhibitory Factor, hLIF) (Carrier Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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