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| Product Name | LIF, Recombinant, Mouse (Differentiation-Stimulating Factor, D Factor, Leukemia Inhibitory Factor) |
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| Description | Purity ~95% (SDS-PAGE). LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. Source: Recombinant protein corresponding to mouse LIF expressed in E. coli. Molecular Weight: ~20kD Biological Activity: The ED50 was determined by the dose-dependent differentiation of M1 myeloid leukemic cells was found to be in the range of 0.01ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P09056 |
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| Catalog # | 500210 |
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| Order / More Info | LIF, Recombinant, Mouse (Differentiation-Stimulating Factor, D Factor, Leukemia Inhibitory Factor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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