| 产品详情 |
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| Product Name | AG-126 |
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| Description | Purity >95%. Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 µM. It blocks the production of TNF-Alpha in vitro 2 and in vivo, attenuating signaling through NF-?B, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 µM)6 and platelet-derived GFRK (IC50 > 100 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile, Tyrphostin AG-126 |
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| Gene, Accession, CAS # | CAS: 118409-62-4 |
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| Catalog # | LS-H6429 |
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| Order / More Info | AG-126 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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