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| Product Name | AG-370 |
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| Description | Purity >95%. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile, NSC 651712 |
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| Gene, Accession, CAS # | CAS: 134036-53-6 |
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| Catalog # | LS-H6441 |
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| Price | |
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| Order / More Info | AG-370 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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