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| Product Name | AG-490 |
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| Description | Purity >98% by NMR, TLC. AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock. AG-490 is a useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N~-(phenylmethyl)-2-propenamide |
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| Gene, Accession, CAS # | CAS: 133550-30-8 |
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| Catalog # | LS-H14586 |
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| Order / More Info | AG-490 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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