| 产品详情 |
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| Product Name | AG-825 |
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| Description | Purity >98%. The HER2/Neu proto-oncogene is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTK) which includes EGFR, HER2/Neu, HER3 and HER4. Overexpression of HER2/Neu occurs in 25-30% of human breast and ovarian cancer. AG-825 is a selective ATP-competitive inhibitor of the tyrosine kinase activity of HER2/Neu. In cell-free assays, AG-825 inhibits Her2/Neu, EGFR, and PDGFR autophosphorylation with IC50 values of 0.35, 19, and 40 µM, respectively. However, in select whole cells, the high concentration of ATP prevents inhibition of kinase activity by AG-825. Concentrations of 50 µM AG-825, however, consistently inhibit Her2/Neu signalling and promote killing of human LNCaP, C4, and C4-2 prostate cancer cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide, Tyrphostin AG-825 |
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| Gene, Accession, CAS # | CAS: 149092-50-2 |
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| Catalog # | LS-H6444 |
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| Price | |
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| Order / More Info | AG-825 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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