| 产品详情 |
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| Product Name | AG-879 |
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| Description | Purity >95%. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors. AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 µM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 µM), and the VEGF receptor FLK1 (IC50 = ~1 µM). Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 µM) in schwannoma cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[3,5-bis (1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2E-propenethioamide, Tyrphostin AG-879 |
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| Gene, Accession, CAS # | CAS: 148741-30-4 |
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| Catalog # | LS-H6445 |
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| Price | |
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| Order / More Info | AG-879 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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