| 产品详情 |
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| Product Name | AG957 |
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| Description | Purity >95%. Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl ), as well as normal c-Abl (IC50 s = 4.3, 1, and 7.1 µM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester, NSC 654705, Tyrphostin AG957 |
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| Gene, Accession, CAS # | CAS: 140674-76-6 |
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| Catalog # | LS-H6447 |
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| Price | |
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| Order / More Info | AG957 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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