| 产品详情 |
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| Product Name | MADD, Blocking Peptide |
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| Description | Purified 60-70%. Peptide corresponding to amino acids 1570 to 1588 of human MADD (1). The sequence of immunogenic peptide is identical to that of DENN and differs by one amino acid with rat GDP/GTP exchange protein Rab3-GEP (2,5). MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains (1). Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2 (1). MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3) (2, 3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP (4, 5). MADD is 87% identical to KIAA0358, a brain protein of unknown function (4). Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GE |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MADD, Blocking Peptide (MAP Kinase-activating Death Domain Protein, Differentially Expressed in Normal and Neoplastic Cells, DENN, Insulinoma Glucagonoma Clone 20, IG20, KIAA0358, Rab3 GDP/GTP Exchange Factor, RAB3GEP) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M1500P |
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| Price | |
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| Order / More Info | MADD, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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