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| Product Name | Macrophage Inflammatory Protein 1 alpha, aa24-92, Recombinant, Rat (MIP-1a, CCL3) |
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| Description | Purity ~95% (SDS-PAGE). CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1a) and LD78, is a member of the B or CC subfamily of chemokines and is closely related to CCL4/MIP-1B. Chemokines comprise a large family of small secreted proteins that are involved in immune and inflammatory responses. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells (1). Mature rat CCL3 shares 74%, 91%, 88% aa sequence identity with human, mouse, and cotton rat CCL3, respectively (2). CCL3 is an ~8kD chemokine that forms complexes with sulfated proteoglycans (3, 4). In a reversible process, CCL3 associates into noncovalently-linked dimers which then form tetramers and high molecular weight polymers (5, 6). These complexes of CCL3 are protected from proteolytic digestion by insulin degrading enzyme (IDE) which can cleave the monomeric chemokine (6). CCL3 exerts its biological functions through interactions with CCR1, CCR3, |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P50229 |
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| Catalog # | M1202-10D |
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| Order / More Info | Macrophage Inflammatory Protein 1 alpha, aa24-92, Recombinant, Rat (MIP-1a, CCL3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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