| 产品详情 |
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| Product Name | QIK, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). QIK is a serine/threonine protein kinase that contains an N-terminal kinase domain, a central domain with ubiquitin-associate motif, and a C-terminal PKA phosphorylation site. QIK can phosphorylate IRS1 and overexpression of QIK in adipocyte elevates the phosphorylation of IRS1. The QIK-mediated phosphorylation of IRS1 may modulate the efficiency of insulin signal transduction and could be responsible for insulin resistance associated with diabetes. Insulin disrupts TORC2 activity by induction of QIK which then stimulates the phosphorylation and cytoplasmic translocation of TORC2. Phosphorylated TORC2 is subsequently degraded by the 26S proteasome. Source: Recombinant protein corresponding to human QIK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~150kD Specific Activity: 112nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | QIK, Recombinant, Human, GST-Tag (Salt-inducible Kinase 2, Serine/threonine-protein Kinase SIK2, SIK-2, Qin-induced Kinase, SNF1LK2, SIK2, KIAA0781, LOH11CR1I) |
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| Gene, Accession, CAS # | Accession: NM_015191 |
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| Catalog # | 500416 |
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| Order / More Info | QIK, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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