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| Product Name | RyR-Calstabin Interaction Stabilizer, S107 |
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| Description | Purity ≥98% (HPLC). A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2.5ug/0.25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo. Synonyms: 7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217763 |
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| Order / More Info | RyR-Calstabin Interaction Stabilizer, S107 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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