| 产品详情 |
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| Product Name | DP2 Antagonist I |
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| Description | Purity ~98% (HPLC). A cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 2.0 and 2.4nM against 1.5nM PGD2 for human & murine DP2 binding, respectively), exhibiting much reduced potency against DP1 (Ki = 1.58uM; IC50 = 10uM), PGE receptor EP2 (54% inhibition at 10uM), and little or no activity toward 49 other receptors and ion channels. Effectively inhibits PGD2-induced cellular activation (IC50 = 32 and 80nM, respectively, using CHO-CRTH2 or human whole blood) in vitro and is efficacious in alleviating airway eosinophil infiltration in OVA-sensitized mice (30mg/kg; p.o.) in vivo with good oral bioavailability. Solubility: DMSO Primary Target: DP2 Primary Target Ki: 2nM Molar Mass: 406.88 |
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| Size | 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DP2 Antagonist I (CRTH2 Antagonist I, GPR44 Antagonist I, (4-Chloro-2-((2-methyl-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217323 |
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| Price | |
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| Order / More Info | DP2 Antagonist I from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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