| 产品详情 |
| Edit |   |
|---|
| Product Name | DP2 Antagonist II |
|---|
| Description | Purity ~93% (HPLC). The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 5.3 and 5.0nM against human & murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I, but less oral bioavailability in mice. Solubility: DMSO Primary Target: DP2 Primary Target Ki: 5.3nM Molar Mass: 451.23 |
|---|
| Size | 2mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1'-(5-chloro-2-fluorobenzyl)-2,2',5'-trioxospiro(indole-3,3→-pyrrolidin)-1(2H)-yl)acetic Acid) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217324 |
|---|
| Price | |
|---|
| Order / More Info | DP2 Antagonist II from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|