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| Product Name | Fibrinogen (Pg & vWF Depleted), Human (Factor 1) |
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| Description | Purity ~95% (SDS-PAGE). Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of wheth |
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| Size | 500mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | FGA, Gene ID: 2243, SwissProt: P02671 |
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| Catalog # | 301208 |
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| Price | |
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| Order / More Info | Fibrinogen (Pg & vWF Depleted), Human (Factor 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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