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| Product Name | Fibrinogen, Plasminogen Depleted, Human (Coagulation Factor I) |
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| Description | Homogeneous by SDS-PAGE and ≥95% clottable. Plasminogen has been depleted by affinity chromatography. Fibrinogen is an abundant plasma protein (5-10uM) produced in the liver. The intact protein has a molecular weight of 340kD and is composed of 3 pairs of disulfide-bound polypeptide chains named Aalpha, Bbeta and gamma. Fibrinogen is a triglobular protein consisting of a central E domain and terminal D domains. Proteolysis by thrombin results in release of Fibrinopeptide A (FPA, Aa1-16) followed by Fibrinopeptide B (FPB, Bb1-14) and the fibrin monomers that result polymerize in a half-overlap fashion to form insoluble fibrin fibrils. The chains of fibrin are referred to as a, b and g, due to the removal of FPA and FPB. The polymerized fibrin is subsequently stabilized by the transglutaminase activated Factor XIII that forms amide linkages between g chains and, to a lesser extent, a chains of the fibrin molecules. Proteolysis of fibrinogen by plasmin initially liberates C-terminal resi |
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| Size | 25mg, 100mg, 500mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FGA Protein; Fibrinogen A alpha Polypeptide, Fibrinogen alpha Chain, FGA, Fibrinogen B alpha Polypeptide, Fibrinogen beta Chain, FGB, Fibrinogen G alpha Polypeptide, Fibrinogen gamma Chain, FGG, Fib2, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405, PRO2061 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F4200 |
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| Order / More Info | Fibrinogen, Plasminogen Depleted, Human (Coagulation Factor I) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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