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| Product Name | PELI2, 1-420aa, Human, His tag, E Coli |
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| Description | MW: 48.8 kDa (443aa) confirmed by MALDI-TOF. Purity >80% by SDS-PAGE. PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but no |
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| Size | 0.05 mg, 0.25 mg |
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| Concentration | 0.5 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [E3 ubiquitin-protein ligase pellino homolog 2; PELI2 - pellino E3; Pellino-2] |
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| Gene, Accession, CAS # | PELI2, Gene ID: 57161, Accession: NP_067078 |
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| Catalog # | MBS205987 |
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| Order / More Info | PELI2, 1-420aa, Human, His tag, E Coli from MYBIOSOURCE INC. |
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| Product Specific References | Jensen L.E., et al (2003). FEBS Lett. 545:199-202; Strelow A., et al (2003). FEBS Lett. 547:157-161 |
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