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| Product Name | Catenin, beta, BioAssay™ ELISA Kit (Human) |
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| Description | A key downstream effector in the Wnt signaling pathway is b-catenin (1). It is implicated in two major biological processes of vertebrates: early embryonic development (2) and tumorigenesis (3). Casein kinase 1 phosphorylates b-catenin on Ser45. This phosphorylation event primes b-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3b destabilizes b-catenin by phosphorylating it at Ser33, 37 and Thr41 (7). Mutations in these phosphorylation sites which result in the stabilization of b-catenin protein levels have been found in many tumor cell lines (8). This ELISA Kit is a solid phase sandwich enzyme-linked im munosorbent assay (ELISA) that detects endogenous levels of total beta-catenin protein (phosphorylated and non-phosphorylated). A beta-Catenin antibody has been coated onto the microwells. After incubation with cell lysates, both phospho- and nonphospho-beta-catenin proteins are captured by the coated antibody antibody. Following extensive washing, beta-Catenin mouse monocl |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2069-38 |
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| Order / More Info | Catenin, beta, BioAssay™ ELISA Kit (Human) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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