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| Product Name | SR-FLICA Poly Caspase Assay Kit |
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| Description | Description: Assay for apoptosis via poly caspase activation with the red SR FLICA Poly Caspase Assay Kit. This in vitro, whole cell caspase assay employs the red fluorescent caspase inhibitor probe SR-VAD-FMK to label activated caspase enzymes in living cells or tissue samples. Analyze the fluorescent signal in whole cells using fluorescence microscopy, a fluorescent plate reader, or by flow cytometry (green or yellow laser required to detect SR). Methodology: FLICA caspase and apoptosis detect |
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| Size | 25 tests, 100 tests, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SR-FLICA |
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| Catalog # | MBS258012 |
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| Price | |
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| Order / More Info | SR-FLICA Poly Caspase Assay Kit from MYBIOSOURCE INC. |
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| Product Specific References | Slee, E. A., C. Adrain, and S. J. Maritin. (1999) Serial Killers: ordering caspase activation events in apoptosis. Cell Death Differ. 6:1067-1074. Earnshaw, W.C., Martins, L.M., and Kaufmann, S.H. (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Ann. Rev. Biochem. 68:383-424. Hengartner, M.O. (2000) The biochemistry of apoptosis. Nature 407:770-816. Degterev, A., Boyce, M., and Yuan, J. (2003) A decade of caspases. Oncogene 22:8543-8567. Nicholson, D.W. (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death.Cell Death Differ. 6:1028-1042. Thornberry, N.A., and Lazebnik, Y. (1998) Caspases: enemies within. Science 281:1312-1316. Cryns, V., and Yuan, J. (1998) Proteases to die for. Genes Dev. 12:1551 - 1570. Talanian, R.V., Quinlan, C., Trautz, S., Hackett, M.C., Mankovich, J.A., Banach, D., Ghayur, T., Brady, K.D., and Wong, W.W. (1997) Substrate specificities of caspase family proteases. J. Biol. Chem. 272:9677 - 9682. Garcia-Calvo, M., Peterson, E.P., Leiting, B., Ruel, R., Nicholson, D.W., and Thornberry, N.A. (1998) Inhibition of human caspases by peptide-based macromolecular inhibitors. J. Biol. Chem. 273:32608 - 32613. Rauber, P., Angliker, H., Walker, B., and Shaw, E. (1986) The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteases and cysteine proteinases. Biochem. J. 239:633-640. Ekert, P.G., Silke, J., and Vaux, D.L. (1999) Caspase inhibitors. Cell Death Differ. 6:1081-1086. Bedner, E., Smolewski, P., Amstas, P., and Darzynkiewicz, Z. (2000) Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp. Cell Res. 259:308-313. Amstad, P.A., Yu, G., Johnson, G.L., Lee, B.W., Dhawan, S., and Phelps, D.J. (2001) Detection of caspase activation in situ by fluorochrome-labeled caspase inhibitors. BioTechniques 31:608-610. Smolewski, P., Bedner, E., Du, L., Hsieh, T.C., Wu, J.M., Phelps, D.J., and Darzynkiewicz, Z. (2001) Detection of caspase activation by fluorochrome -labeled inhibitors: multiparameter analysis by laser scanning cytometry. Cytometry 44:73-82. |
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