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| Product Name | BTNL2, Recombinant, Mouse, aa26-457 (Butyrophilin-like Protein 2) |
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| Description | Purity ~98% (SDS-PAGE). Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy. Source: Recombinant protein corresponding to aa26-457 from mouse BTNL2, fused to the N-terminus of the Fc region of mouse IgG2a, expressed in CHO cells. Biological Activity: A butyrophilin-like molecule that functions to inhibit T cell activation. Endotoxin: ~0.06 |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207096 |
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| Order / More Info | BTNL2, Recombinant, Mouse, aa26-457 (Butyrophilin-like Protein 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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