| 产品详情 |
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| Product Name | Rac1 Inhibitor (NSC23766) |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50~50uM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50-100uM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50=50 mM and 64mM, respectively). Synonyms: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4- pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride CAS No: 1177865-17-6 |
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| Size | 5mg, 10mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4- pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 29597 |
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| Order / More Info | Rac1 Inhibitor (NSC23766) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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