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| Product Name | p38 MAP Kinase Inhibitor X, BIRB 796 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50=8 and 97nM, respectively, against human p38a, respectively, with or without 2h preincubation), but high affinity (t1/2 of dissociation from human p38a=23h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2a2 and c-Raf-1 only at much higher concentrations (IC50=98nM and 1.4uM, respectively) and displays little or no activity toward 10 other kinases (IC50>20uM). Shown to inhibit LPS-induced TNF-a production both in vitro (IC50=18 and 780nM using THP-1 cells and in human whole blood, respectively) and in mice in vivo (by 84%; 30mg/kg p.o.). Formula: C31H37N5O3 Solubility: DMSO Molecular Weight: 527.7 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | p38 MAP Kinase Inhibitor X, BIRB 796 (1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217617 |
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| Order / More Info | p38 MAP Kinase Inhibitor X, BIRB 796 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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