| 产品详情 |
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| Product Name | PLX-7904 |
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| Description | MW: 512.54. Purity ≥98% by HPLC. PLX7904 is a potent and selective paradox-breaker RAF inhibitor. PLX7904 efficiently inhibits activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. Importantly; it inhibits ERK1/2 phosphorylation in mutant BRAF melanoma cells with acquired resistance to Vemurafenib/PLX4720 that is mediated by a secondary mutation in NRAS. Consistent with ERK1/2 reactivation driving the re-acquisition of malignant p |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [5- (2-Cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl (methyl) sulfamoyl]amino]-2; 6-difluorobenzoyl]-1H-pyrrolo[2; 3-b]pyridine] |
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| Gene, Accession, CAS # | CAS: 1393465-84-3 |
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| Catalog # | MBS846391 |
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| Order / More Info | PLX-7904 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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