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| Product Name | Epigen, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Epigen (EPGN) is an epithelial mitogen that belongs to the EGF superfamily (1-3). Human Epigen cDNA encodes a 154aa residue type I transmembrane precursor glycoprotein with a 22 aa signal peptide, an 88 aa extracellular domain, a 21 aa transmembrane domain and a 23 aa cytoplasmic domain (2, 3). The extracellular domain (aa 23-110) contains a pattern of six cysteines typical of EGF family proteins (1-3). Potential splice variants of 133, 112, 103, 94 or 73 aa, lacking either N-terminal sequence (aa 15 or 36 to 44), transmembrane and juxtamembrane sequence (aa 87 or 96 to 137), or sequences in both regions, have been described (4). In addition to potentially secreted splice variants, Epigen is among several EGF family proteins that can undergo metalloproteinase cleavage to generate a soluble form (3, 5). Cleavage of Epigen by TACE/ADAM17 has been demonstrated (5). The mature, shed form of human Epigen (aa 54-104) shares 92%, 94% and 94% aa sequence identity with m |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6UW88 |
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| Catalog # | E3376-25D |
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| Price | |
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| Order / More Info | Epigen, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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