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| Product Name | (R)-Acenocoumarol |
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| Description | Purity >98%. Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro . Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 hours) and slower plasma clearance (1.9 L/hour), compared to the (S)-enantiomer (1.8 hours, 28.5 L/hour). The R-enantiomer is rapidly absorbed from the gastrointestinal tract with essentially complete oral bioavailability, whereas (S)-acenocoumarol undergoes extensive first-pass metabolism. Perhaps related to these pharmacokinetic characteristics, (R)-acenocoumarol is more potent in vivo as an anti-coagulant than the (S)-enantiomer. As the clearance of acenocoumarol is ~20-fold faster than that for warfarin, the plasma concentrations of acenocoumarol are substantially lower than those for warfarin in patients receiving long-term treatment. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-hydroxy-3-[(1R)-1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one, (R)-Acenocoumarin, (R)-Nicoumalone |
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| Gene, Accession, CAS # | CAS: 66556-77-2 |
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| Catalog # | LS-H5636 |
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| Order / More Info | (R)-Acenocoumarol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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