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| Product Name | DYNLL1, Recombinant, Human, aa1-89, GST-Tag (Dynein Light Chain 1, Cytoplasmic Domain) |
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| Description | Purity ~90% (SDS-PAGE). Acts as one of several non-catalytic accessory components of the Cytoplasmic domain dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic domain dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from Cytoplasmic domain dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Source: Recombinant protein corresponding to aa1-89 from human DYNLL1, fused to GST-Tag at N-terminal expressed |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8kD dynein light chain, DLC8 Dynein light chain LC8-type 1, Protein inhibitor of neuronal nitric oxide synthase, PIN |
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| Gene, Accession, CAS # | SwissProt: P63167 |
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| Catalog # | 373114 |
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| Order / More Info | DYNLL1, Recombinant, Human, aa1-89, GST-Tag (Dynein Light Chain 1, Cytoplasmic Domain) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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