| 产品详情 |
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| Product Name | Recombinant Human Bifunctional polynucleotide phosphatase/kinase |
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| Description | 1-521aa; Full Length. MW: 73kD. Purity >90% as determined by SDS-PAGE. Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either roving 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphatase; Including the following 2 domains; Polynucleotide 3'-phosphatase; EC=3.1.3.32; 2'(3')-polynucleotidase; Polynucleotide 5'-hydroxyl-kinase (EC:2.7.1.78)] |
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| Gene, Accession, CAS # | PNKP, Gene ID: 11284, Accession: NP_009185.2 |
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| Catalog # | MBS1298034 |
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| Order / More Info | Recombinant Human Bifunctional polynucleotide phosphatase/kinase from MYBIOSOURCE INC. |
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| Product Specific References | Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.Jilani A., Ramotar D., Slack C., Ong C., Yang X.M., Scherer S.W., Lasko D.D.J. Biol. Chem. 274:24176-24186(1999) Molecular characterization of a human DNA kinase.Karimi-Busheri F., Daly G., Robins P., Canas B., Pappin D.J.C., Sgouros J., Miller G.G., Fakhrai H., Davis E.M., Le Beau M.M., Weinfeld M.J. Biol. Chem. 274:24187- |
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