| 产品详情 |
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| Product Name | Recombinant Human Bile acid receptor |
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| Description | 1-476aa; Full Length of Isoform 3. MW: 70.8kD. Purity >90% as determined by SDS-PAGE. Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14] |
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| Gene, Accession, CAS # | NR1H4, Gene ID: 9971, Accession: NP_001193906.1 |
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| Catalog # | MBS1345556 |
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| Order / More Info | Recombinant Human Bile acid receptor from MYBIOSOURCE INC. |
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| Product Specific References | The identification of the cDNA coding for HRR-1, a novel human farnesol receptor.Papetti M., Wood N., Lohmar P.D., Bowman M.R.Functional analysis of human farnesol receptor (NR1H4) splicing variant.Han J.-I., Bok S.-H., Jeong T.-S.Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.Huber R.M., Murphy K., Miao B., Link J.R., Cunningham M.R., Rupar M.J., Gunyuzlu P.L., Haws T.F. Jr., Kassam A., Powell F., Hollis G.F., Young P.R., Mukherjee R., Burn T.C.Gen |
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